Publications
Innovative and Impactful Solution for Advanced Research
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Microfluidic Mechanical Reactivation of Aged Stem Cells
본 연구는 건국대학교 조쌍구 교수 연구팀과의 협력을 통해 개발된, 세포 재생 및 재활성화를 위한 마이크로플루이딕 세포 압축 플랫폼(μ-CPR)에 관한 내용입니다.
이번 연구에서는 기계적 자극만으로도 노화된 줄기세포를 재생하고 재활성화할 수 있음을 확인했으며, 노화 지표를 감소시키는 동시에 세포 증식 능력과 줄기세포성을 효과적으로 회복시킬 수 있음을 입증했습니다.
특히, 본 결과는 세포 기능의 재프로그래밍에 있어 유전적·화학적 요인을 넘어 생물물리학적 신호가 핵심적인 역할을 할 수 있음을 보여준다는 점에서 의미가 있습니다.
더 나아가, 이 기술은 현재 연구 단계를 넘어 실제 적용으로 확장되고 있습니다. MxT Biotech를 통해 피부 미용 및 재생의학 분야에서 상용화를 적극 추진 중이며, 정밀한 세포 활성화 기술을 기반으로 새로운 치료 가능성을 열어가고 있습니다.
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.online published (Mar 30, 2026) Pager UTL -
Microfluidic Hydroporation Platform for Effective Allogeneic CAR-T Cell Production and Subsequent Functional Cytotoxicity Analysis
ADVANCED MATERIALS TECHNOLOGIES (Impact Factor = 6.2), 11 February 2026,
DOI: 10.1002/admt.202502210online published (Feb 11, 2026) Pager UTL -
Fractal-shaped droplet microfluidics for highly scalable cell mechanoporation
Lab on a Chip(Impact Factor = 5.4), 06 January 2026, 26, 10-17
DOI: 10.1039/D5LC00865D
online published (Jan 06, 2026) Pager UTL -
Advancing Allogeneic NK Cell Immunotherapy through Microfluidic Gene Delivery
Advanced Science(Impact factor =14.3), 07 March 2025, 2198-3844
DOI: 10.1002/advs.202412544online published (Mar 07, 2025) Pager UTL -
Highly efficient CRISPR-mediated genome editing through microfluidic droplet cell mechanoporation
Nature Communications (Impact factor = 14.7),16 September 2024 Article number: 8099
DOI: 10.1038/s41467-024-52493-1online published (Sep 16, 2024) Pager UTL -
Expanding CAR-T cell immunotherapy horizons through microfluidics
Lab on a Chip (Impact factor = 6.1), 2024, 24, 1088-1120
DOI: 10.1039/D3LC00622Konline published (Jan 04, 2024) Pager UTL -
Genetically Stable and Scalable Nanoengineering of Human Primary T Cells via Cell Mechanoporation
Nano Letters (Impact factor = 9.6), 2023, 23, 16, 7341–7349
DOI: 10.1021/acs.nanolett.3c01720online published (Jul 28, 2023) Pager UTL -
Highly efficient mRNA delivery with nonlinear microfluidic cell stretching for cellular engineering
Lab on a Chip (Impact factor = 6.1), 2023, 23, 1758-1767
DOI: 10.1039/D2LC01115Honline published (Feb 02, 2023) Pager UTL -
Highly Efficient Transfection of Human Primary T Lymphocytes Using Droplet-Enabled Mechanoporation
ACS Nano (Impact factor = 17.1), 2021, 15, 8, 12888–12898
DOI: 10.1021/acsnano.0c10473online published (Jun 18, 2021) Pager UTL -
Microfluidic and Nanofluidic Intracellular Delivery
Advanced Science (Impact factor = 14.3), 2021, 8(15), 2004595
DOI: 10.1002/advs.202170090online published (Jun 06, 2021) Pager UTL -
Microfluidic Cell Stretching for Highly Effective Gene Delivery into Hard-to-Transfect Primary Cells
ACS Nano (Impact factor = 17.1), 2020, 14, 11, 15094–15106
DOI: 10.1021/acsnano.0c05169online published (Oct 09, 2020) Pager UTL -
Intracellular Nanomaterial Delivery via Spiral Hydroporation
ACS Nano (Impact factor = 17.1), 2020, 14, 3, 3048–3058
DOI: 10.1021/acsnano.9b07930online published (Feb 18, 2020) Pager UTL -
Hydroporator: a hydrodynamic cell membrane perforator for high-throughput vector-free nanomaterial intracellular delivery and DNA origami biostability evaluation
Lab on a Chip (Impact factor = 6.1), 2019, 19, 1747-1754
DOI: 10.1039/c9lc00041konline published (Apr 09, 2018) Pager UTL -
Intracellular Delivery of Nanomaterials via an Inertial Microfluidic Cell Hydroporator
Nano Letters (Impact factor = 9.6), 2018, 18, 4, 2705–2710.
DOI: 10.1021/acs.nanolett.8b00704online published (Mar 23, 2018) Pager UTL